DNA methylation Markers in the Detection of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a poor prognosis. Epigenetic modification been shown to be deregulated during HCC development by dramatically impacting differentiation, proliferation function of cells. One important epigenetic DNA methylation which methyl groups are added cytosines without changing sequence itself. Studies found that methylated markers can specific for detection HCC. On basis these findings utility as novel biomarkers early-stage measured in blood, indeed superior sensitivity specificity have several studies when compared current surveillance methods. However, variety factors currently limit immediate application exciting biomarkers. In this review, we provide detailed rationalization approach use detection, summarize recent on focusing importance etiological cause disease mechanisms leading cancer.